CAMK4 anticorps
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- Antigène Voir toutes CAMK4 Anticorps
- CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CAMK4 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- Recombinant protein corresponding to the C-terminus of human CAMKIV.
- Clone
- 3F11
- Isotype
- IgG
- Top Product
- Discover our top product CAMK4 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
- Autre désignation
- CAMK4 (CAMK4 Produits)
- Synonymes
- anticorps CaMK IV, anticorps CaMK-GR, anticorps IV, anticorps caMK, anticorps CAMK4, anticorps A430110E23Rik, anticorps AI666733, anticorps CaMKIV, anticorps CaMKIV/Gr, anticorps D18Bwg0362e, anticorps Ccdpk, anticorps RATCCDPK, anticorps camk4-A, anticorps wu:fj42a03, anticorps zgc:110275, anticorps calcium/calmodulin dependent protein kinase IV, anticorps calcium/calmodulin-dependent protein kinase IV, anticorps calcium/calmodulin-dependent protein kinase IV L homeolog, anticorps CAMK4, anticorps Camk4, anticorps camk4.L, anticorps camk4
- Sujet
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Synonyms: Calcium/calmodulin-dependent protein kinase type IV, CaM kinase-GR, CaMK IV, CAMK4, CAMK, CAMK-GR, CAMKIV
Background: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
- ID gène
- 814
- UniProt
- Q16566
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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