Complement Factor H anticorps

N° du produit ABIN6943395

Détail du produit anti-Complement Factor H anticorps

Antigène: Complement Factor H (CFH)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Complement Factor H est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Full length protein

Clone: 6F11

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Complement Factor H

Antigène: Complement Factor H (CFH)

Autre désignation: Factor H (CFH Produits)

Synonymes: anticorps AHUS1, anticorps AMBP1, anticorps ARMD4, anticorps ARMS1, anticorps CFHL3, anticorps FH, anticorps FHL1, anticorps HF, anticorps HF1, anticorps HF2, anticorps HUS, anticorps Mud-1, anticorps NOM, anticorps Sas-1, anticorps Sas1, anticorps Fh, anticorps CFH, anticorps im:7147412, anticorps si:ch211-207o17.2, anticorps fH, anticorps armd4, anticorps arms1, anticorps cfh, anticorps cfhl3, anticorps fhl1, anticorps hf1, anticorps hf2, anticorps hus, anticorps complement factor H, anticorps complement component factor h, anticorps complement factor H-related protein 5, anticorps complement factor H L homeolog, anticorps CFH, anticorps Cfh, anticorps cfh, anticorps LOC100399888, anticorps LOC100733902, anticorps cfh.L

Sujet:

Synonyms: Complement factor H, H factor 1, CFH, HF, HF1, HF2

Background: A glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self-markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

ID gène: 3075

UniProt: P08603

Pathways: Système du Complément, Cellular Response to Molecule of Bacterial Origin