Recombinant Complement Factor H anticorps

N° du produit ABIN6943395

Cet anticorps Lapin Monoclonal détecte spécifiquement Complement Factor H dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Complement Factor H anticorps (ABIN6943395)

Antigène: Complement Factor H (CFH)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Complement Factor H est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Complement Factor H anticorps

Fonction: CFH Recombinant Antibody

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Full length protein

Isotype: IgG

Information d'application

Indications d'application: WB(WB(1:500-2000))

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Complement Factor H

Antigène: Complement Factor H (CFH)

Autre désignation: Factor H

Sujet:

Synonyms: Complement factor H, H factor 1, CFH, HF, HF1, HF2

Background: A glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self-markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

ID gène: 3075

UniProt: P08603

Pathways: Système du Complément, Cellular Response to Molecule of Bacterial Origin