Growth Hormone Receptor anticorps

N° du produit ABIN6943577

Cet anticorps anti-Growth Hormone Receptor est un anticorps Lapin Monoclonal détectant Growth Hormone Receptor dans WB, FACS, IF (cc), IF (p) et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Growth Hormone Receptor anticorps (ABIN6943577)

Antigène: Growth Hormone Receptor (GHR)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Growth Hormone Receptor est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3C5

Détail du produit anti-Growth Hormone Receptor anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Synthetic peptide within human Growth hormone receptor aa 500-630

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Growth Hormone Receptor

Antigène: Growth Hormone Receptor (GHR)

Autre désignation: Growth hormone receptor

Sujet:

Synonyms: Growth hormone receptor, Somatotropin receptor, Growth hormone-binding protein, Serum-binding protein, GH receptor, GH-binding protein, GHBP, GHR.

Background: GHR is a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. It is a receptor for pituitary gland growth hormone involved in regulating postnatal body growth. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene

ID gène: 2690

UniProt: P10912

Pathways: Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus