PPP1CB anticorps

N° du produit ABIN6944649

Cet anticorps Lapin Monoclonal détecte spécifiquement PPP1CB dans WB, IP et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour PPP1CB anticorps (ABIN6944649)

Antigène: PPP1CB (Protein Phosphatase 1, Catalytic Subunit, beta Isoform (PPP1CB))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PPP1CB est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6G6

Détail du produit anti-PPP1CB anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein corresponding to human PPP1CB aa 100-327.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IP(1-2 μg)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PPP1CB

Antigène: PPP1CB (Protein Phosphatase 1, Catalytic Subunit, beta Isoform (PPP1CB))

Autre désignation: PPP1CB

Sujet:

Synonyms: Serine/threonine-protein phosphatase PP1-beta catalytic subunit, Protein phosphatase 1 catalytic subunit beta, PP-1B, PPP1CD, PP1beta

Background: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

ID gène: 5500

UniProt: P62140

Pathways: M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism