CD25 anticorps
-
- Antigène Voir toutes CD25 (IL2RA) Anticorps
- CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
-
Reactivité
- Souris
-
Hôte
- Rat
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp CD25 est non-conjugé
-
Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- Purification
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- niveau d'endotoxine
- Low endotoxin: < 0.01 EU/ug
- Clone
- PC61-5
- Isotype
- IgG1 lambda
- Top Product
- Discover our top product IL2RA Anticorps primaire
-
-
- Indications d'application
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Commentaires
-
2 mg/mL
- Restrictions
- For Research Use only
-
- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, pH 7.2
- Agent conservateur
- Azide free
- Stock
- 4 °C
- Stockage commentaire
- 2-8°C
- Date de péremption
- 12 months
-
- Antigène
- CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
- Autre désignation
- CD25 (IL2RA Produits)
- Synonymes
- anticorps CD25, anticorps IDDM10, anticorps IL2R, anticorps TCGFR, anticorps IL2RAC, anticorps IL-2RA, anticorps Il2r, anticorps Ly-43, anticorps interleukin 2 receptor subunit alpha, anticorps interleukin-2 receptor subunit alpha-like, anticorps interleukin 2 receptor, alpha chain, anticorps IL2RA, anticorps Il2ra, anticorps LOC100222957
- Sujet
- The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL- 2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells. The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used for depletion of Treg cells in vivo, as well as to distinguish Treg cells from naive or conventional T cells which are CD25-.
- ID gène
- 16184
- UniProt
- P01590
- Pathways
- Signalistation JAK/STAT, Growth Factor Binding, Activated T Cell Proliferation
-