APOB anticorps

N° du produit ABIN6963944

Cet anticorps Souris Monoclonal détecte spécifiquement APOB dans WB et ELISA. Il présente une réactivité envers Humain et Non-Human Primate et a été mentionné dans 5+ publications.

Aperçu rapide pour APOB anticorps (ABIN6963944)

Antigène: APOB (Apolipoprotein B (APOB))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOB est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: LDL 20-17

Détail du produit anti-APOB anticorps

Specificité: Native apoB in the form of LDL.

Réactivité croisée (Details): The monoclonal antibody cross-reacts with apoB from non-human primates.

Purification: Purified from in vitro cultures by protein G affinity chromatography.

Immunogène: Human LDL

Isotype: IgG2a

Information d'application

Indications d'application: For quantification of apoB in serum/plasma samples and cell culture supernatants using ELISA. LDL 20/17 is recommended as coating mAb in combination with detection mAb LDL 11 . The antibodies are also suitable for immunoprecipitation and Western blot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: supplied at 1 mg/mL in PBS with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Date de péremption: 18 months

Références pour anticorps anti-APOB (ABIN6963944)

Yu, Rimbert, Palmer, Toyohara, Xia, Xia, Ferreira, Chen, Chen, Loaiza, Horwitz, Kacergis, Zhao, Soukas, Kuivenhoven, Kathiresan, Cowan: "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis." dans: Cell, Vol. 179, Issue 6, pp. 1276-1288.e14, (2020) (PubMed).

Cayo, Mallanna, Di Furio, Jing, Tolliver, Bures, Urick, Noto, Pashos, Greseth, Czarnecki, Traktman, Yang, Morrisey, Grompe, Rader, Duncan: "A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia." dans: Cell stem cell, Vol. 20, Issue 4, pp. 478-489.e5, (2017) (PubMed).

Vu, Bemis, Benson, Bista, Carney, Fahrner, Lee, Liu, Lonkar, Milne, Nichols, Picarella, Shoelson, Smith, Ting, Wensley, Yeager, Zimmer, Jirousek: "Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid." dans: Journal of medicinal chemistry, Vol. 59, Issue 3, pp. 1217-31, (2016) (PubMed).

Bissig-Choisat, Wang, Legras, Saha, Chen, Bell, Pankowicz, Hill, Barzi, Leyton, Leung, Kruse, Himes, Goss, Wilson, Chan, Lagor, Bissig: "Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model." dans: Nature communications, Vol. 6, pp. 7339, (2015) (PubMed).

Derwall, Malhotra, Lai, Beppu, Aikawa, Seehra, Zapol, Bloch, Yu: "Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 32, Issue 3, pp. 613-22, (2012) (PubMed).

Détails sur APOB

Antigène: APOB (Apolipoprotein B (APOB))

Autre désignation: apoB

ID gène: 338

Pathways: Lipid Metabolism