CDK9 anticorps (N-Term)

N° du produit ABIN6971511

Détail du produit anti-CDK9 anticorps

Antigène: CDK9 (Cyclin-Dependent Kinase 9 (CDK9))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK9 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: CDK9 (cyclin-dependent kinase 9) is a protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. CDK9 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This antibody was raised against a peptide within the N-terminal region of human CDK9.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur CDK9

Antigène: CDK9 (Cyclin-Dependent Kinase 9 (CDK9))

Autre désignation: CDK9 (CDK9 Produits)

Synonymes: anticorps C-2k, anticorps CDC2L4, anticorps CTK1, anticorps PITALRE, anticorps TAK, anticorps wu:fb22e09, anticorps wu:fc06c02, anticorps c-2k, anticorps cdc2l4, anticorps cdk9, anticorps ctk1, anticorps pitalre, anticorps tak, anticorps CDK9, anticorps CG5179, anticorps Dmel\\CG5179, anticorps P-TEF, anticorps P-TEFb, anticorps PTefb, anticorps cyclin dependent kinase 9, anticorps cyclin-dependent kinase 9 (CDC2-related kinase), anticorps cyclin-dependent kinase 9 L homeolog, anticorps cyclin-dependent kinase 9, anticorps Cyclin-dependent kinase 9, anticorps cyclin-dependent kinase 9 S homeolog, anticorps CDK9, anticorps cdk9, anticorps cdk9.L, anticorps Cdk9, anticorps cdk9.S

Poids moléculaire: 44 kDa

NCBI Accession: NP_001252

Pathways: Cycle Cellulaire