MCM2 anticorps (pSer53) (AbBy Fluor® 555)

N° du produit ABIN6978136

Cet anticorps Lapin Polyclonal détecte spécifiquement MCM2 dans IF (p) et IF (cc). Il présente une réactivité envers Humain.

Aperçu rapide pour MCM2 anticorps (pSer53) (AbBy Fluor® 555) (ABIN6978136)

Antigène: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM2 est conjugé à/à la AbBy Fluor® 555

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-MCM2 anticorps (AbBy Fluor® 555)

Épitope: pSer53

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Sheep,Pig,Horse,Chicken,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated Synthesised phosphopeptide derived from human MCM2 around the phosphorylation site of Ser53

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MCM2

Antigène: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Autre désignation: MCM2

Sujet:

Synonyms: MCM4 (phospho S53), MCM2(phospho-Ser53), MCM2(phospho Ser53), MCM2 (phospho S54), p-MCM2(Ser53), p-MCM2(S53), rat MCM4 (phospho S54), BM28, CCNL 1, CCNL1, CDC like 1, CDC like-1, cdc19, CDCL 1, CDCL1, Cell devision cycle like 1, Cyclin like 1, cyclin like-1, D3S3194, DNA replication licensing factor MCM2, KIAA0030, MCM 2, MCM2, MCM2 minichromosome maintenance deficient 2 mitotin, MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae), MCM2 minichromosome maintenance deficient 2, mitotin, MCM2_HUMAN, MCM2_MOUSE, MGC10606, Minichromosome maintenance complex component 2, Minichromosome maintenance deficient 2 (mitotin), Minichromosome maintenance deficient 2 mitotin, Minichromosome maintenance protein 2, Minichromosome maintenance protein 2 homolog, Mitotin, Nuclear protein BM28, OTTHUMP00000216047, OTTHUMP00000216050.

Background: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

ID gène: 4171

UniProt: P49736

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA