RUNX2 anticorps (AA 201-300) (Biotin)

N° du produit ABIN6982730

L’anticorps Lapin Polyclonal anti-RUNX2 a été validé pour WB et ELISA. Il convient pour détecter RUNX2 dans des échantillons de Humain et Souris.

Aperçu rapide pour RUNX2 anticorps (AA 201-300) (Biotin) (ABIN6982730)

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUNX2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA

Détail du produit anti-RUNX2 anticorps (Biotin)

Épitope: AA 201-300

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RUNX2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur RUNX2

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Autre désignation: RUNX2

Sujet:

Synonyms: RUNX2_HUMAN, Runt-related Transcription Factor 2, CBF alpha 1, CBF-alpha-1, PEBP2-alpha A, CBFA1, CCD, CCD1, Cleidocranial dysplasia 1, Core binding factor, Core binding factor runt domain alpha subunit 1, Core binding factor subunit alpha 1, MGC120023, Oncogene AML 3, OSF 2, OSF2, OSF-2, Osteoblast specific transcription factor 2, OTTHUMP00000016533, PEA2 alpha A, PEA2aA, PEBP2 alpha A, PEBP2A1, PEBP2A2, PEBP2aA1, Polyomavirus enhancer binding protein 2 alpha A subunit, Runt domain, Runt related transcription factor 2, SL3 3 enhancer factor 1 alpha A subunit, SL3/AKV core binding factor alpha A subunit, AML3, CLCD.

Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. [SUBUNIT] Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4.

ID gène: 860

UniProt: Q13950