SOCS3 anticorps (AA 161-225) (Biotin)

N° du produit ABIN6982999

Cet anticorps Lapin Polyclonal détecte spécifiquement SOCS3 dans WB. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour SOCS3 anticorps (AA 161-225) (Biotin) (ABIN6982999)

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS3 est conjugé à/à la Biotin

Application: Western Blotting (WB)

Détail du produit anti-SOCS3 anticorps (Biotin)

Épitope: AA 161-225

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SOCS3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3

Sujet:

Synonyms: suppressor of cytokine signaling 3, ATOD4, CIS 3, CIS3, Cish3, Cytokine induced SH2 protein 3, E2a Pbx1 target gene in fibroblasts 10, EF 10, MGC71791, SOCS 3, SOCS-3, SSI 3, SSI3, STAT induced STAT inhibitor 3, Suppressor of cytokine signaling 3, SOCS3_HUMAN.

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

ID gène: 9021

UniProt: O14543

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C