TTC3 anticorps (AA 251-350) (HRP)

N° du produit ABIN6987799

Cet anticorps Lapin Polyclonal détecte spécifiquement TTC3 dans IHC (p). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour TTC3 anticorps (AA 251-350) (HRP) (ABIN6987799)

Antigène: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTC3 est conjugé à/à la HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TTC3 anticorps (HRP)

Épitope: AA 251-350

Réactivité croisée: Souris, Rat

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RNF105

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TTC3

Antigène: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Autre désignation: RNF105

Sujet:

Synonyms: DCRR1, E3 ubiquitin protein ligase TTC3, E3 ubiquitin-protein ligase TTC3, Protein DCRR1, RING finger protein 105,Tetratricopeptide repeat protein 3 (TPR repeat protein D), Tetratricopeptide repeat protein 3, TPR repeat protein 3, TPR repeat protein D, TPRD, TPRDI, TPRDII, TPRDIII, TTC3, TTC3_HUMAN.

Background: E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation, its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

ID gène: 7267

UniProt: P53804