CHCHD2 anticorps

N° du produit ABIN6989760

Cet anticorps anti-CHCHD2 Polyclonal Lapin (ABIN6989760) détecte spécifiquement CHCHD2 dans WB, IF et IF (cc). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CHCHD2 anticorps (ABIN6989760)

Antigène: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHCHD2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-CHCHD2 anticorps

Fonction: CHCHD2 Polyclonal Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000), IF(ICC)(1:50-200), IF(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CHCHD2

Antigène: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Autre désignation: CHCHD2

Sujet:

Synonyms: CHCHD2,C7orf17,MNRR1,NS2TP,PARK22

Background: The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.

ID gène: 51142

UniProt: Q9Y6H1