FADD anticorps

N° du produit ABIN6989786

L’anticorps anti-FADD Polyclonal Lapin est utilisé pour la détection de FADD dans des échantillons de Humain. Il a été validé pour WB, IHC et IP.

Aperçu rapide pour FADD anticorps (ABIN6989786)

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FADD est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-FADD anticorps

Fonction: FADD Polyclonal Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1).

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000), IP(1-2 μg), IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur FADD

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Autre désignation: FADD

Sujet:

Synonyms: GIG3,MORT1,FADD,FADD

Background: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

ID gène: 8772

UniProt: Q13158

Pathways: Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades