INPP5D anticorps (pTyr1020)

N° du produit ABIN6989964

Cet anticorps anti-INPP5D est un anticorps Lapin Monoclonal détectant INPP5D dans WB, IP et IF (cc). Adapté pour Humain.

Aperçu rapide pour INPP5D anticorps (pTyr1020) (ABIN6989964)

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp INPP5D est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 1H11

Détail du produit anti-INPP5D anticorps

Épitope: pTyr1020

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Synthetic phospho-Peptide corresponding to residues surrounding Tyr1020 of human SHIP.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IF(ICC) 1:50-200
IP(1-2 μg)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: SHIP

Sujet:

Synonyms: Inositol polyphosphate 5 phosphatase of 145 kDa antibody, 4 antibody, 5-trisphosphate 5-phosphatase 1 antibody, hp51CN antibody, Inositol polyphosphate 5 phosphatase 145 kDa antibody, Inositol polyphosphate 5 phosphatase antibody, Inositol polyphosphate-5-phosphatase of 145 kDa antibody, INPP5D antibody, MGC104855 antibody, MGC142140 antibody, MGC142142 antibody, p150Ship antibody, Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody, Phosphatidylinositol-3 antibody, SH2 containing inositol phosphatase isoform b antibody, SH2 domain containing inositol 5' phosphatase 1 antibody, SH2 domain containing inositol phosphatase 1 antibody, SH2 domain-containing inositol phosphatase 1 antibody, SH2 domain-containing inositol-5'-phosphatase 1 antibody, SHIP-1 antibody, SHIP1 antibody, SHIP1_HUMAN antibody, Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody, SIP-145 antibody, SIP145 antibody

Background: SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.

ID gène: 3635

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg