XBP1 anticorps (AA 2-160)

N° du produit ABIN6990193

Cet anticorps Souris Monoclonal détecte spécifiquement XBP1 dans WB, ELISA, ICC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour XBP1 anticorps (AA 2-160) (ABIN6990193)

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp XBP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 3H1G4

Détail du produit anti-XBP1 anticorps

Épitope: AA 2-160

Purification: XBP-1 Monoclonal Antibody is Protein A purified.

Immunogène: Mouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.

Isotype: IgG1

Information d'application

Indications d'application: XBP-1 antibody can be used for the detection of XBP-1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL. For immunofluorescence start at 4 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: XBP-1 Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: XBP-1 monoclonal antibody can be stored at -20°C, stable for one year.

Détails sur XBP1

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP-1

Sujet: XBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.

ID gène: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response