ORAI1 anticorps (C-Term)

N° du produit ABIN6990201

Cet anticorps anti-ORAI1 Monoclonal Souris (Clone 6D11A11) (ABIN6990201) détecte spécifiquement ORAI1 dans WB, ELISA, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ORAI1 anticorps (C-Term) (ABIN6990201)

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ORAI1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6D11A11

Détail du produit anti-ORAI1 anticorps

Épitope: C-Term

Specificité: ORAI1 antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Purification: ORAI1 Monoclonal Antibody is Protein A purified.

Immunogène: Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.

Isotype: IgG2b

Information d'application

Indications d'application: ORAI1 antibody can be used for detection of ORAI1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: ORAI1 monoclonal antibody can be stored at -20°C, stable for one year.

Détails sur ORAI1

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Autre désignation: ORAI1

Sujet: ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.

Poids moléculaire: Predicted: 33 kDa

Observed: 50 kDa

ID gène: 84876

UniProt: Q96D31

Pathways: TCR Signaling, BCR Signaling