PD-L1 anticorps (Extracellular Domain)

N° du produit ABIN6990233

L’anticorps Souris Monoclonal anti-PD-L1 a été validé pour WB, ELISA, IF, ICC et IHC (p). Il convient pour détecter PD-L1 dans des échantillons de Humain et Souris.

Aperçu rapide pour PD-L1 anticorps (Extracellular Domain) (ABIN6990233)

Antigène: PD-L1 (CD274 (PD-L1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-L1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6H10

Détail du produit anti-PD-L1 anticorps

Épitope: Extracellular Domain

Specificité: PD-L1 Antibody has no cross-reactivity to PD-L2.

Purification: PD-L1 Antibody is supplied as protein A purified IgG1.

Immunogène: Anti-PD-L1 antibody was raised against the extracellular domain of human PD-L1.

Isotype: IgG1

Information d'application

Indications d'application: WB: 0.25 - 4 μ,g/mL, IF: 2 μ,g/mL, IHC-P: 5 μ,g/mL, ICC: 1 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry, Immunocytochemistry and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PD-L1 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PD-L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PD-L1

Antigène: PD-L1 (CD274 (PD-L1))

Autre désignation: PDL1

Sujet: PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response (1). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (2,3). Through a yet unknown activating receptor, it may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (4).

Poids moléculaire: Predicted: 33kD

Observed: 37kD kDa

ID gène: 29126

NCBI Accession: NP_054862

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints