PD-L1 anticorps (Extracellular Domain)
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- Antigène Voir toutes PD-L1 Anticorps
- PD-L1 (CD274 (PD-L1))
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Épitope
- Extracellular Domain
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PD-L1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- PD-L1 Antibody has no cross-reactivity to PD-L2.
- Purification
- PD-L1 Antibody is supplied as protein A purified IgG1.
- Immunogène
- Anti-PD-L1 antibody was raised against the extracellular domain of human PD-L1.
- Clone
- 6H10
- Isotype
- IgG1
- Top Product
- Discover our top product PD-L1 Anticorps primaire
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- Indications d'application
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WB: 0.25 - 4 μ,g/mL, IF: 2 μ,g/mL, IHC-P: 5 μ,g/mL, ICC: 1 μ,g/mL.
Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry, Immunocytochemistry and Immunofluorescence in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PD-L1 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- PD-L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- PD-L1 (CD274 (PD-L1))
- Autre désignation
- PDL1 (PD-L1 Produits)
- Synonymes
- anticorps B7-H, anticorps B7H1, anticorps PD-L1, anticorps PDCD1L1, anticorps PDCD1LG1, anticorps PDL1, anticorps A530045L16Rik, anticorps B7h1, anticorps Pdcd1l1, anticorps Pdcd1lg1, anticorps Pdl1, anticorps RGD1566211, anticorps CD274 molecule, anticorps CD274 antigen, anticorps programmed cell death 1 ligand 2, anticorps CD274, anticorps Cd274, anticorps PDCD1LG2
- Sujet
- PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response (1). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (2,3). Through a yet unknown activating receptor, it may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (4).
- Poids moléculaire
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Predicted: 33kD
Observed: 37kD kDa - ID gène
- 29126
- NCBI Accession
- NP_054862
- UniProt
- Q9NZQ7
- Pathways
- Cancer Immune Checkpoints
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