GFRA2 anticorps (AA 360-410)

N° du produit ABIN6990251

L’anticorps anti-GFRA2 Polyclonal Lapin est utilisé pour la détection de GFRA2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et ICC.

Aperçu rapide pour GFRA2 anticorps (AA 360-410) (ABIN6990251)

Antigène: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFRA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-GFRA2 anticorps

Épitope: AA 360-410

Purification: GFR alpha 2 Antibody is Ion exchange chromatography purified.

Immunogène: GFR alpha 2 antibody was raised against a 15 amino acid peptide near the center of human GFR alpha 2. The immunogen is located within amino acids 360 - 410 of GFR alpha 2.

Isotype: IgG

Information d'application

Indications d'application: GFR alpha 2 antibody can be used for detection of GFR alpha 2 by Western blot at 1 μ,g/mL. A 52 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: GFR alpha 2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: GFR alpha 2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur GFRA2

Antigène: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Autre désignation: GFR alpha 2

Sujet: GFR alpha 2 Antibody: Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently. NTNRalpha was also termed GDNFRβ, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRα,-2 recently. GFRα,-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRα,-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

Poids moléculaire: Predicted: 51 kDa

Observed: 52 kDa

ID gène: 2675

UniProt: O00451