BACE2 anticorps (C-Term)

N° du produit ABIN6990329

L’anticorps Lapin Polyclonal anti-BACE2 a été validé pour WB, ELISA et IHC (p). Il convient pour détecter BACE2 dans des échantillons de Humain.

Aperçu rapide pour BACE2 anticorps (C-Term) (ABIN6990329)

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BACE2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BACE2 anticorps

Épitope: C-Term

Purification: BACE2 Antibody is affinity chromatography purified via peptide column.

Immunogène: BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2. The immunogen is located within the last 50 amino acids of BACE2.

Isotype: IgG

Information d'application

Indications d'application: BACE2 antibody can be used for detection of BACE2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: BACE2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: BACE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur BACE2

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Autre désignation: BACE2

Sujet: BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

Poids moléculaire: Predicted: 57 kDa

Observed: 57 kDa

ID gène: 25825

UniProt: Q9Y5Z0