TBK1 anticorps (C-Term)

N° du produit ABIN6990357

Cet anticorps anti-TBK1 est un anticorps Lapin Polyclonal détectant TBK1 dans WB, ELISA et ICC. Adapté pour Humain et Souris.

Aperçu rapide pour TBK1 anticorps (C-Term) (ABIN6990357)

Antigène: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-TBK1 anticorps

Épitope: C-Term

Specificité: No cross response to IKKa, IKKb, IKKy, or IKKe.

Purification: NAK Antibody is affinity chromatography purified via peptide column.

Immunogène: NAK antibody was raised against a synthetic peptide corresponding to 17 amino acids form near the carboxy terminus of human NAK/TBK1. The immunogen is located within the last 50 amino acids of NAK.

Isotype: IgG

Information d'application

Indications d'application: NAK antibody can be used for detection of NAK/TBK1 by Western blot. An 84 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NAK Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NAK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TBK1

Antigène: TBK1 (TANK-Binding Kinase 1 (TBK1))

Autre désignation: NAK

Sujet: NAK Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ,B is associated with Iκ,B proteins in the cell cytoplasm, which inhibit NF-κ,B activity. Phosphorylation of I-kappaB by Iκ,B kinase (IKK) complex leads to degradation of I-kappaB and activation of NF-κ,B. The IKK complex contains IKKα, IKKβ, and IKKγ,. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-κ,B-activating kinase), and T2K. NAK/TBK1 activates IKKβ, through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-κ,B activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

Poids moléculaire: 84 kDa

ID gène: 29110

NCBI Accession: NP_037386

UniProt: Q9UHD2

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome