IRAK3 anticorps (C-Term)

N° du produit ABIN6990358

Cet anticorps Lapin Polyclonal détecte spécifiquement IRAK3 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour IRAK3 anticorps (C-Term) (ABIN6990358)

Antigène: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRAK3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IRAK3 anticorps

Épitope: C-Term

Specificité: IRAK-M antibody is predicted to have no cross reactivity to other members of the IRAK family.

Purification: IRAK-M Antibody is affinity chromatography purified via peptide column.

Immunogène: IRAK-M antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRAK-M. The immunogen is located within the last 50 amino acids of IRAK-M.

Isotype: IgG

Information d'application

Indications d'application: IRAK-M antibody can be used for detection of IRAK-M by Western blot at 1 μ,g/mL. IRAK-M antibody can also detect IRAK-M by immunohistochemistry at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in mouse and rat samples, Immunohistochemistry in human and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IRAK-M Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IRAK-M antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur IRAK3

Antigène: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Autre désignation: IRAK-M

Sujet: IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.

Poids moléculaire: Predicted: 66 kDa

Observed: 70 kDa

ID gène: 11213

NCBI Accession: NP_009130

UniProt: Q9Y616

Pathways: Signalisation TLR, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades