RRM2B anticorps (N-Term)

N° du produit ABIN6990359

L’anticorps anti-RRM2B Polyclonal Lapin est utilisé pour la détection de RRM2B dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, ELISA, IF et IHC (p).

Aperçu rapide pour RRM2B anticorps (N-Term) (ABIN6990359)

Antigène: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRM2B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-RRM2B anticorps

Épitope: N-Term

Specificité: At least six isoforms of p53R2 are known to exist, this antibody will detect all but the largest isoform.

Purification: p53R2 Antibody is affinity chromatography purified via peptide column.

Immunogène: p53R2 antibody was raised against a 16 amino acid peptide near the amino terminus of human p53R2. The immunogen is located within the first 50 amino acids of p53R2.

Isotype: IgG

Information d'application

Indications d'application: p53R2 antibody can be used for detection of p53R2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: p53R2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: p53R2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur RRM2B

Antigène: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Autre désignation: p53R2

Sujet: P53R2 Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.

Poids moléculaire: Predicted: 39 kDa

Observed: 43 kDa

ID gène: 50484

UniProt: Q7LG56

Pathways: Signalisation p53, Negative Regulation of intrinsic apoptotic Signaling