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DR4 anticorps (C-Term)

DR4 Reactivité: Humain, Rat, Souris WB, ELISA, IF, ICC, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990419
  • Antigène Voir toutes DR4 Anticorps
    DR4 (Drought-Repressed 4 Protein (DR4))
    Épitope
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 33
    • 16
    • 9
    • 2
    Humain, Rat, Souris
    Hôte
    • 28
    • 5
    Lapin
    Clonalité
    • 28
    • 5
    Polyclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DR4 est non-conjugé
    Application
    • 24
    • 9
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    DR4 antibody has no cross reaction to DR5
    Purification
    DR4 Antibody is Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Anti-DR4 antibody was raised against a peptide corresponding to 19 amino acids near the carboxy terminus of human DR4. The immunogen is located within the last 50 amino acids of DR4.
    Isotype
    IgG
    Top Product
    Discover our top product DR4 Anticorps primaire
  • Indications d'application
    WB: 1 μ,g/mL, IHC-P: 10 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunocytochemistry in human samples and Immunofluorescence in human and rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    DR4 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    DR4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    DR4 (Drought-Repressed 4 Protein (DR4))
    Autre désignation
    DR4 (DR4 Produits)
    Synonymes
    anticorps APO2, anticorps CD261, anticorps DR4, anticorps TRAILR-1, anticorps TRAILR1, anticorps TNF receptor superfamily member 10a, anticorps TNFRSF10A
    Sujet
    DR4 Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL2, 3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-κ,B activation in many tissues and cells.
    Poids moléculaire
    Predicted: 50kD

    Observed: 55kD (Post-modification: 1 N-linked glycosylation) kDa
    ID gène
    8797
    UniProt
    O00220
    Pathways
    Apoptose, Positive Regulation of Endopeptidase Activity
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