TRIM5 anticorps (Middle Region)

N° du produit ABIN6990447

Cet anticorps anti-TRIM5 est un anticorps Lapin Polyclonal détectant TRIM5 dans WB, ELISA, IHC (p) et IF. Adapté pour Humain.

Aperçu rapide pour TRIM5 anticorps (Middle Region) (ABIN6990447)

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-TRIM5 anticorps

Épitope: AA 370-420, Middle Region

Purification: TRIM5 alpha Antibody is affinity chromatography purified via peptide column.

Immunogène: TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the mid-region of human TRIM5 alpha. The immunogen is located within amino acids 370 - 420 of TRIM5 alpha.

Isotype: IgG

Information d'application

Indications d'application: TRIM5 alpha antibody can be used for detection of TRIM5 alpha by Western blot at 2 μ,g/mL. A band at approximately 55 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRIM5 alpha Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TRIM5 alpha antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TRIM5

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Autre désignation: TRIM5 alpha

Sujet: TRIM5 alpha Antibody: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5α, variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5α, variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5α, acts as a natural barrier to cross-species retrovirus transmission.

ID gène: 85363

NCBI Accession: NP_149023

UniProt: Q9C035

Pathways: Activation of Innate immune Response