Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) anticorps

N° du produit ABIN6990479

L’anticorps Lapin Polyclonal anti- a été validé pour WB, ELISA et IHC (p). Il convient pour détecter dans des échantillons de Humain et Souris.

Aperçu rapide pour Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) anticorps (ABIN6990479)

Antigène: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit

Purification: NADE Antibody is Ion exchange chromatography purified.

Immunogène: NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE. The immunogen is located within the last 50 amino acids of NADE.

Isotype: IgG

Information d'application

Indications d'application: NADE antibody can be used for detection of NADE by Western blot at 1 μ,g/mL. Despite its predicted molecular weight, NADE migrates at ~23 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NADE Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NADE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détail du antigène

Antigène: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Autre désignation: NADE

Sujet: NADE Antibody: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

ID gène: 27018

NCBI Accession: NP_996798

UniProt: Q00994

Pathways: Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity