ECSIT anticorps (C-Term)

N° du produit ABIN6990485

L’anticorps Lapin Polyclonal anti-ECSIT a été validé pour WB, ELISA et IHC (p). Il convient pour détecter ECSIT dans des échantillons de Humain et Souris.

Aperçu rapide pour ECSIT anticorps (C-Term) (ABIN6990485)

Antigène: ECSIT

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ECSIT est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ECSIT anticorps

Épitope: AA 290-340, C-Term

Purification: ECSIT Antibody is Ion exchange chromatography purified.

Immunogène: ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT. The immunogen is located within amino acids 290 - 340 of ECSIT.

Isotype: IgG

Information d'application

Indications d'application: ECSIT antibody can be used for detection of ECSIT by Western blot at 0.5 to 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ECSIT Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ECSIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ECSIT

Antigène: ECSIT

Autre désignation: ECSIT

Sujet: ECSIT Antibody: Activation of NF-κ,B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

ID gène: 51295

NCBI Accession: NP_057665

UniProt: Q9BQ95

Pathways: Signalisation TLR, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome