Tuberin anticorps (C-Term)

N° du produit ABIN6990537

Cet anticorps anti-Tuberin Polyclonal Lapin (ABIN6990537) détecte spécifiquement Tuberin dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Tuberin anticorps (C-Term) (ABIN6990537)

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tuberin est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Tuberin anticorps

Épitope: AA 1450-1500, C-Term

Purification: TSC2 Antibody is affinity chromatography purified via peptide column.

Immunogène: TSC2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human TSC2. The immunogen is located within amino acids 1450 - 1500 of TSC2.

Isotype: IgG

Information d'application

Indications d'application: TSC2 antibody can be used for the detection of TSC2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TSC2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TSC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Tuberin

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Autre désignation: TSC2

Sujet: TSC2 Antibody: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.

Poids moléculaire: Predicted: 200 kDa

Observed: 200 kDa

ID gène: 7249

NCBI Accession: NP_000539

UniProt: P49815

Pathways: Signalisation RTK, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus