XBP1 anticorps (C-Term)

N° du produit ABIN6990606

Cet anticorps anti-XBP1 est un anticorps Lapin Polyclonal détectant XBP1 dans WB, ELISA et ICC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour XBP1 anticorps (C-Term) (ABIN6990606)

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XBP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-XBP1 anticorps

Épitope: C-Term

Purification: XBP-1 Antibody is affinity chromatography purified via peptide column.

Immunogène: XBP-1 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human XBP-1. The immunogen is located within the last 50 amino acids of XBP-1.

Isotype: IgG

Information d'application

Indications d'application: XBP-1 antibody can be used for the detection of XBP-1 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: XBP-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: XBP-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur XBP1

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP-1

Sujet: XBP-1 Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.

ID gène: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response