Clusterin anticorps (Isoform 1)

N° du produit ABIN6990650

L’anticorps Lapin Polyclonal anti-Clusterin a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter Clusterin dans des échantillons de Humain et Souris.

Aperçu rapide pour Clusterin anticorps (Isoform 1) (ABIN6990650)

Antigène: Clusterin (CLU)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Clusterin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Clusterin anticorps

Épitope: Isoform 1

Purification: Clusterin Antibody is affinity chromatography purified via peptide column.

Immunogène: Clusterin antibody was raised recombinant human Clusterin isoform 1.

Isotype: IgG

Information d'application

Indications d'application: Clusterin antibody can be used for the detection of Clusterin by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Clusterin Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Clusterin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: Clusterin

Sujet: Clusterin Antibody: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.

ID gène: 1191

NCBI Accession: NP_001822

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling