TANK anticorps (N-Term)

N° du produit ABIN6990660

Cet anticorps anti-TANK est un anticorps Lapin Polyclonal détectant TANK dans WB, ELISA et ICC. Adapté pour Humain.

Aperçu rapide pour TANK anticorps (N-Term) (ABIN6990660)

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TANK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-TANK anticorps

Épitope: AA 60-110, N-Term

Purification: TANK Antibody is affinity chromatography purified via peptide column.

Immunogène: TANK antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TANK. The immunogen is located within amino acids 60 - 110 of TANK.

Isotype: IgG

Information d'application

Indications d'application: TANK antibody can be used for the detection of TANK by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TANK Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TANK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TANK

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Autre désignation: TANK

Sujet: TANK Antibody: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κ,B. This activation of NF-κ,B occurs through an association with the kinases IKKε, and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the Iκ,B complex. This suggests that in addition to the possibility that TBK1 and IKKε, activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-κ,B proteins. At least two isoforms of TANK are known to exist.

ID gène: 10010

NCBI Accession: NP_004171

UniProt: Q92844

Pathways: Signalisation p53, Signalisation TLR, Activation of Innate immune Response