TIGAR anticorps (AA 100-150)

N° du produit ABIN6990720

Cet anticorps anti-TIGAR est un anticorps Lapin Polyclonal détectant TIGAR dans ELISA, WB, IHC (p) et IF. Adapté pour Humain et Souris.

Aperçu rapide pour TIGAR anticorps (AA 100-150) (ABIN6990720)

Antigène: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIGAR est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-TIGAR anticorps

Épitope: AA 100-150

Purification: TIGAR Antibody is affinity chromatography purified via peptide column.

Immunogène: TIGAR antibody was raised against a 19 amino acid synthetic peptide from near the center of human TIGAR. The immunogen is located within amino acids 100 - 150 of TIGAR.

Isotype: IgG

Information d'application

Indications d'application: TIGAR antibody can be used for detection of TIGAR by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TIGAR Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TIGAR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TIGAR

Antigène: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Autre désignation: TIGAR

Sujet: TIGAR Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.

ID gène: 57103

NCBI Accession: NP_065108

UniProt: Q9NQ88

Pathways: L'effet Warburg