STIM1 anticorps (C-Term)

N° du produit ABIN6990744

Cet anticorps anti-STIM1 est un anticorps Lapin Polyclonal détectant STIM1 dans WB, ELISA, IHC (p) et IF. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour STIM1 anticorps (C-Term) (ABIN6990744)

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STIM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-STIM1 anticorps

Épitope: C-Term

Specificité: At least two isoforms of STIM1 are known to exist, this antibody will detect only the larger form. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.

Purification: STIM1 Antibody is affinity chromatography purified via peptide column.

Immunogène: STIM1 antibody was raised against a 24 amino acid synthetic peptide from near the carboxy terminus of human STIM1. The immunogen is located within the last 50 amino acids of STIM1.

Isotype: IgG

Information d'application

Indications d'application: STIM1 antibody can be used for detection of STIM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: STIM1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: STIM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur STIM1

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Autre désignation: STIM1

Sujet: STIM1 Antibody: In T lymphocytes, the sole pathway for Ca²⁺ entry following antigen-receptor binding is through store-operated Ca²⁺-release-activated Ca²⁺ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca²⁺ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca²⁺ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca²⁺ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca²⁺ entry.

Poids moléculaire: Predicted: 59, 75, 87 kDa

Observed: 88 kDa

ID gène: 6786

NCBI Accession: NP_003147

UniProt: Q13586

Pathways: TCR Signaling, BCR Signaling