TARDBP anticorps (AA 160-210)

N° du produit ABIN6990776

L’anticorps Lapin Polyclonal anti-TARDBP a été validé pour WB, ELISA, IF et ICC. Il convient pour détecter TARDBP dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TARDBP anticorps (AA 160-210) (ABIN6990776)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-TARDBP anticorps

Épitope: AA 160-210

Specificité: At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.

Purification: TDP43 Antibody is affinity chromatography purified via peptide column.

Immunogène: TDP43 antibody was raised against a 18 amino acid synthetic peptide from near the center of human TDP43. The immunogen is located within amino acids 160 - 210 of TDP43.

Isotype: IgG

Information d'application

Indications d'application: TDP43 antibody can be used for detection of TDP43 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TDP43 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TDP43 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TDP43

Sujet: TDP43 Antibody: TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

Poids moléculaire: Predicted: 46 kDa

Observed: 46 kDa

ID gène: 23435

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion