CDCA8 anticorps (N-Term)

N° du produit ABIN6990958

Cet anticorps Lapin Polyclonal détecte spécifiquement CDCA8 dans WB, ELISA et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour CDCA8 anticorps (N-Term) (ABIN6990958)

Antigène: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDCA8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-CDCA8 anticorps

Épitope: N-Term

Purification: CDCA8 Antibody is affinity chromatography purified via peptide column.

Immunogène: CDCA8 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8. The immunogen is located within the first 50 amino acids of CDCA8.

Isotype: IgG

Information d'application

Indications d'application: CDCA8 antibody can be used for detection of CDCA8 by Western blot at 1 and 2 μ,g/mL. Antibody can also be used for immunoflourescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CDCA8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CDCA8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CDCA8

Antigène: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Autre désignation: CDCA8

Sujet: CDCA8 Antibody: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.

ID gène: 55143

NCBI Accession: NP_060571

UniProt: Q53HL2

Pathways: Cycle Cellulaire, M Phase