PALB2 anticorps (C-Term)

N° du produit ABIN6991161

Cet anticorps anti-PALB2 est un anticorps Lapin Polyclonal détectant PALB2 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour PALB2 anticorps (C-Term) (ABIN6991161)

Antigène: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PALB2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PALB2 anticorps

Épitope: AA 940-990, C-Term

Specificité: At least four isoforms of PALB2 are known to exist, this antibody will detect all four isoforms.

Purification: PALB2 Antibody is affinity chromatography purified via peptide column.

Immunogène: PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2. The immunogen is located within amino acids 940 - 990 of PALB2.

Isotype: IgG

Information d'application

Indications d'application: PALB2 antibody can be used for detection of PALB2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PALB2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PALB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PALB2

Antigène: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Autre désignation: PALB2

Sujet: PALB2 Antibody: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.

Poids moléculaire: Predicted: 65, 100, 130 kDa

Observed: 140 kDa

ID gène: 79728

UniProt: Q86YC2

Pathways: Réparation de l'ADN