TNIP3 anticorps (C-Term)

N° du produit ABIN6991170

Cet anticorps anti-TNIP3 est un anticorps Lapin Polyclonal détectant TNIP3 dans WB, ELISA et IHC (p). Adapté pour Humain et Souris.

Aperçu rapide pour TNIP3 anticorps (C-Term) (ABIN6991170)

Antigène: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNIP3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TNIP3 anticorps

Épitope: C-Term

Purification: ABIN3 Antibody is affinity chromatography purified via peptide column.

Immunogène: ABIN3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ABIN3. The immunogen is located within the last 50 amino acids of ABIN3.

Isotype: IgG

Information d'application

Indications d'application: ABIN3 antibody can be used for detection of ABIN3 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ABIN3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ABIN3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TNIP3

Antigène: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Autre désignation: ABIN3

Sujet: ABIN3 Antibody: The nuclear factor NF-κ,B plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-κ,B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-κ,B activation. ABIN3 is a 39 kDa protein that negatively regulates NF-κ,B activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-κ,B inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-κ,B in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

ID gène: 79931

NCBI Accession: NP_079149

UniProt: Q96KP6

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin