NLRP4 anticorps (AA 330-380)

N° du produit ABIN6991401

Cet anticorps anti-NLRP4 Polyclonal Lapin (ABIN6991401) détecte spécifiquement NLRP4 dans ELISA et WB. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour NLRP4 anticorps (AA 330-380) (ABIN6991401)

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP4 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-NLRP4 anticorps

Épitope: AA 330-380

Purification: NALP4 Antibody is affinity chromatography purified via peptide column.

Immunogène: NALP4 antibody was raised against a 13 amino acid synthetic peptide near the center of human NALP4. The immunogen is located within amino acids 330 - 380 of NALP4.

Isotype: IgG

Information d'application

Indications d'application: NALP4 antibody can be used for detection of NALP4 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NALP4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NALP4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur NLRP4

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Autre désignation: NALP4

Sujet: NALP4 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-κ,B induction by TNF-α, and IL-1β, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-κ,B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-κ,B activity.

ID gène: 147945

UniProt: Q96MN2

Pathways: Inflammasome