Nibrin anticorps (N-Term)

N° du produit ABIN6991690

Cet anticorps Lapin Polyclonal détecte spécifiquement Nibrin dans WB, ELISA, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Nibrin anticorps (N-Term) (ABIN6991690)

Antigène: Nibrin (NBN)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Nibrin anticorps

Épitope: AA 50-100, N-Term

Specificité: At least three alternatively spliced transcript isoforms of NIBRIN are known to exist.

Purification: NIBRIN Antibody is affinity chromatography purified via peptide column.

Immunogène: NIBRIN antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NIBRIN. The immunogen is located within amino acids 50 - 100 of NIBRIN.

Isotype: IgG

Information d'application

Indications d'application: NIBRIN antibody can be used for detection of NIBRIN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NIBRIN Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NIBRIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: NIBRIN

Sujet: NIBRIN Antibody: NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia.

ID gène: 4683

NCBI Accession: NP_002476

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response