GRK6 anticorps (C-Term)

N° du produit ABIN6991952

L’anticorps Lapin Polyclonal anti-GRK6 a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter GRK6 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GRK6 anticorps (C-Term) (ABIN6991952)

Antigène: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRK6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-GRK6 anticorps

Épitope: C-Term

Specificité: GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.

Purification: GRK6 antibody is affinity chromatography purified via peptide column.

Immunogène: GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6. The immunogen is located within the last 50 amino acids of GRK6.

Isotype: IgG

Information d'application

Indications d'application: GRK6 antibody can be used for detection of GRK6 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: GRK6 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: GRK6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur GRK6

Antigène: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Autre désignation: GRK6

Sujet: The G protein-coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).

Poids moléculaire: Predicted: 63 kDa

Observed: 63 kDa

ID gène: 2870

NCBI Accession: NP_001004106

UniProt: P43250

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Negative Regulation of Transporter Activity