OLIG2 anticorps (N-Term)

N° du produit ABIN6991989

Cet anticorps anti-OLIG2 est un anticorps Lapin Polyclonal détectant OLIG2 dans WB, ELISA, IF et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour OLIG2 anticorps (N-Term) (ABIN6991989)

Antigène: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OLIG2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-OLIG2 anticorps

Épitope: AA 80-130, N-Term

Specificité: OLIG2 antibody is human, mouse and rat reactive. It is predicted to not cross-react with other members of the OLIG family of proteins. At least three isoforms of OLIG2 are known to exist, this antibody will detect all three isoforms.

Purification: OLIG2 antibody is affinity chromatography purified via peptide column.

Immunogène: OLIG2 antibody was raised against a 15 amino acid peptide near the amino terminus of human OLIG2. The immunogen is located within amino acids 80 - 130 of OLIG2.

Isotype: IgG

Information d'application

Indications d'application: OLIG2 antibody can be used for detection of OLIG2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: OLIG2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: OLIG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur OLIG2

Antigène: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Autre désignation: OLIG2

Sujet: The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1). Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2). OLIG2 is first observed in the ventral most p3 progenitor domain of the ventral neural tube while OLIG1 is first expressed in the dorsal portion of the p3 domain (2). Mice overexpressing OLIG2 exhibit impaired potassium channel expression in neural progenitors and proliferation of these cells similar to that seen in Down Syndrome, suggesting that OLIG2 may play a role in this pathology (3).

Poids moléculaire: Predicted: 36 kDa

Observed: 37 kDa

ID gène: 10215

NCBI Accession: NP_005797

UniProt: Q13516