MIB1 anticorps (C-Term)

N° du produit ABIN6992000

L’anticorps Lapin Polyclonal anti-MIB1 a été validé pour ELISA, WB, ICC et IF. Il convient pour détecter MIB1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MIB1 anticorps (C-Term) (ABIN6992000)

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MIB1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-MIB1 anticorps

Épitope: AA 920-970, C-Term

Specificité: MIB1 antibody is human, mouse and rat reactive. At least three isoforms of MIB1 are known to exist.

Purification: MIB1 antibody is affinity chromatography purified via peptide column.

Immunogène: MIB1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human MIB1. The immunogen is located within amino acids 920 - 970 of MIB1.

Isotype: IgG

Information d'application

Indications d'application: MIB1 antibody can be used for detection of MIB1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MIB1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: MIB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur MIB1

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Autre désignation: MIB1

Sujet: The E3 ubiquitin-protein ligase MIB1, also known as Mindbomb homolog 1, contains multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase (1). MIB1 interacts with and regulates the cellular expression of the death-associated protein kinase 1 (DAPK1) protein by promoting its ubiquitination and degradation (1). It also positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis (2).

Poids moléculaire: Predicted: 89, 102, 111 kDa

Observed: 103 kDa

ID gène: 57534

NCBI Accession: NP_065825

UniProt: Q86YT6

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2