ATG4A anticorps (C-Term)

N° du produit ABIN6992095

Cet anticorps Lapin Polyclonal détecte spécifiquement ATG4A dans WB, ELISA et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ATG4A anticorps (C-Term) (ABIN6992095)

Antigène: ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ATG4A anticorps

Épitope: C-Term

Specificité: ATG4A antibody is human, mouse and rat reactive. At least two isoforms of ATG4A are known to exist, this antibody will detect both isoforms. ATG4A is predicted to not cross-react with other ATG4 proteins.

Purification: ATG4A antibody is affinity chromatography purified via peptide column.

Immunogène: ATG4A antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ATG4A. The immunogen is located within the last 50 amino acids of ATG4A.

Isotype: IgG

Information d'application

Indications d'application: ATG4A antibody can be used for detection of ATG4A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATG4A antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ATG4A antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur ATG4A

Antigène: ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))

Autre désignation: ATG4A

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4A, also known as AUTL2, is one of four mammalian orthologs of the yeast ATG4 protein, all four are cysteine proteases (3). ATG4 is required for ATG8 conjugation to phosphatidylethanolamine on autophagosomal membranes. In mammals, each ATG4 homolog shows a selective preference for the ATG8 homologs (4).

Poids moléculaire: Predicted: 48 kDa

Observed: 44 kDa

ID gène: 115201

NCBI Accession: NP_443168

UniProt: Q8WYN0

Pathways: Autophagy