DIS3L2 anticorps (C-Term)

N° du produit ABIN6992168

Détail du produit anti-DIS3L2 anticorps

Antigène: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Épitope: AA 720-770, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIS3L2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist, this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.

Purification: DIS3L2 antibody is affinity chromatography purified via peptide column.

Immunogène: DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2. The immunogen is located within amino acids 720 - 770 of DIS3L2.

Isotype: IgG

Information d'application

Indications d'application: DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DIS3L2 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DIS3L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur DIS3L2

Antigène: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Autre désignation: DIS3L2 (DIS3L2 Produits)

Synonymes: anticorps RGD1560168, anticorps DIS3L2, anticorps DKFZp469O0522, anticorps FAM6A, anticorps PRLMNS, anticorps hDIS3L2, anticorps 4930429A22Rik, anticorps 8030493P09Rik, anticorps DIS3-like 3'-5' exoribonuclease 2, anticorps DIS3 like 3'-5' exoribonuclease 2, anticorps DIS3-like exonuclease 2, anticorps Dis3l2, anticorps DIS3L2, anticorps LOC100344728

Sujet: The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).

Poids moléculaire: Predicted: 97 kDa

Observed: 94 kDa

ID gène: 129563

NCBI Accession: NP_689596

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance