IL-11 anticorps (N-Term)

N° du produit ABIN6992179

Cet anticorps Lapin Polyclonal détecte spécifiquement IL-11 dans WB, ELISA, ICC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour IL-11 anticorps (N-Term) (ABIN6992179)

Antigène: IL-11 (IL11) (Interleukin 11 (IL11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-11 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-IL-11 anticorps

Épitope: AA 40-90, N-Term

Specificité: IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist, this antibody will only detect the longest isoform of IL-11.

Purification: IL-11 Antibody is affinity chromatography purified via peptide column.

Immunogène: IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11. The immunogen is located within amino acids 40 - 90 of IL-11.

Isotype: IgG

Information d'application

Indications d'application: IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-11 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IL-11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur IL-11

Antigène: IL-11 (IL11) (Interleukin 11 (IL11))

Autre désignation: IL-11

Sujet: Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).

Poids moléculaire: Predicted: 20 kDa

Observed: 19 kDa

ID gène: 3589

NCBI Accession: NP_000632

UniProt: P20809

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion