PD-L1 anticorps (Extracellular Domain) (Biotin)
-
- Antigène Voir toutes PD-L1 Anticorps
- PD-L1 (CD274 (PD-L1))
-
Épitope
- Extracellular Domain
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp PD-L1 est conjugé à/à la Biotin
-
Application
- ELISA
- Purification
- PD-L1 Antibody is supplied as protein A purified IgG1.
- Immunogène
- PD-L1 antibody was raised against the extracellular domain of human PD-L1.
- Clone
- 8E12
- Isotype
- IgG1
- Top Product
- Discover our top product PD-L1 Anticorps primaire
-
-
- Indications d'application
- PD-L1 antibody can be used for as detection antibody in Sandwich Elisa at 1 μ,g/mL.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PD-L1 Antibody is supplied in PBS containing 1 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- PD-L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
- Antigène
- PD-L1 (CD274 (PD-L1))
- Autre désignation
- PDL1 (PD-L1 Produits)
- Synonymes
- anticorps B7-H, anticorps B7H1, anticorps PD-L1, anticorps PDCD1L1, anticorps PDCD1LG1, anticorps PDL1, anticorps A530045L16Rik, anticorps B7h1, anticorps Pdcd1l1, anticorps Pdcd1lg1, anticorps Pdl1, anticorps RGD1566211, anticorps CD274 molecule, anticorps CD274 antigen, anticorps programmed cell death 1 ligand 2, anticorps CD274, anticorps Cd274, anticorps PDCD1LG2
- Sujet
- PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).
- ID gène
- 29126
- NCBI Accession
- NP_054862
- UniProt
- Q9NZQ7
- Pathways
- Cancer Immune Checkpoints
-