Desmoplakin anticorps

N° du produit ABIN7237973

Cet anticorps anti-Desmoplakin est un anticorps Lapin Polyclonal détectant Desmoplakin dans IHC et ELISA. Adapté pour Humain et Souris.

Aperçu rapide pour Desmoplakin anticorps (ABIN7237973)

Antigène: Desmoplakin (DSP)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Desmoplakin est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-Desmoplakin anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Synthetic peptide of human DSP

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Desmoplakin

Antigène: Desmoplakin (DSP)

Autre désignation: DSP

Sujet: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.

NCBI Accession: NP_004406

UniProt: P15924

Pathways: Cell-Cell Junction Organization