Glutathione Peroxidase 1 anticorps

N° du produit ABIN7249606

L’anticorps Lapin Polyclonal anti-Glutathione Peroxidase 1 a été validé pour WB. Il convient pour détecter Glutathione Peroxidase 1 dans des échantillons de Souris et Rat.

Aperçu rapide pour Glutathione Peroxidase 1 anticorps (ABIN7249606)

Antigène: Glutathione Peroxidase 1 (GPX1)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutathione Peroxidase 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Glutathione Peroxidase 1 anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse GPX1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 400 μg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Glutathione Peroxidase 1

Antigène: Glutathione Peroxidase 1 (GPX1)

Autre désignation: GPX1

Sujet: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance, therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21.

Poids moléculaire:

Observed_MW: 22 kDa

Calculated_MW: 22 kDa

UniProt: P11352, P04041

Pathways: Thyroid Hormone Synthesis, Sensory Perception of Sound, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome