FAS anticorps

N° du produit ABIN7249652

Cet anticorps Souris Monoclonal détecte spécifiquement FAS dans IHC. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour FAS anticorps (ABIN7249652)

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAS est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: 10E5B10

Détail du produit anti-FAS anticorps

Attributs du produit: Monoclonal Antibody

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse FAS

Isotype: IgG

Information d'application

Indications d'application: IHC 1:200-1:800

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 420 μg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FAS

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Autre désignation: FAS

Sujet: FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.

UniProt: P25445, P25446

Pathways: Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity