Dynactin 1 anticorps

N° du produit ABIN7259741

Cet anticorps anti-Dynactin 1 est un anticorps Lapin Polyclonal détectant Dynactin 1 dans IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Dynactin 1 anticorps (ABIN7259741)

Antigène: Dynactin 1 (DCTN1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynactin 1 est non-conjugé

Application: Immunofluorescence (IF)

Détail du produit anti-Dynactin 1 anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human DCTN1 (NP_001128513.1).

Isotype: IgG

Information d'application

Indications d'application: IF 1:20-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Dynactin 1

Antigène: Dynactin 1 (DCTN1)

Autre désignation: DCTN1

Sujet: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

ID gène: 1639

UniProt: Q14203

Pathways: M Phase, ER-Nucleus Signaling